At high Rext (35 kΩ), it is demonstrated that a tc ⩾ 10 min avoids underestimation not overestimation, whilst at low Rext (100 Ω) 5 min are sufficient, suggesting that sweeps with variable tc are possible.
Although efficient replication of the mini-chromosome in U32 requires the complete set of DnaA-boxes and AT-rich regions, only one of the AT-rich sequences together with part of the DnaA-boxes is sufficient, suggesting the presence of combinatorial alternatives for a functional oriC region of A. mediterranei U32.
The single AP1 site in the MMP-1 promoter was not sufficient, suggesting that it normally requires the binding of other factors to function fully.
But side effects and upcoming resistances reveal that monotherapies with the kinase inhibitors alone are not sufficient suggesting the need for combinatory and/or multitargeted therapies [ 5].
More interestingly, dimer is observed when the nucleotide is not sufficient, suggesting similar assembly process to that of RadB (unpublished data).
However, while the UIM and NEDD8 were both required for UBXD7 binding to the CRL, they were not sufficient, suggesting that flanking residues of the UIM make essential contacts with other elements of the CRL complex.
43 Thus, in order to control tumor growth and decrease the number of surviving cells, a single therapeutic agent will likely not be sufficient, suggesting a need for combination therapies aimed at greater control of tumorigenesis.
Moreover, their existence in sufficient mileage suggests a local culture favoring exercise.
In the later part of his essay Clifford puts forward a view about what it is for evidence to be "sufficient" that suggests a much more moderate stance.
They were sufficient to suggest to him that he was going to be given a fair hearing," the judgment said.
