A patient with T cell-deficient, B cell-sufficient and NK cell-sufficient severe combined immunodeficiency has been identified with mutation in CORO1A gene along with reduced T-cell function that was earlier demonstrated in knock-out mice of coro1a gene with similar phenotypes.
To test whether Ahsa1 was sufficient for severe phenotypes, we injected mRNA encoding human AHSA1 at levels that did not affect wild-type embryos (Fig. 3F).
In this work we used two nitrate levels, 3 mM (or HN) and 0.3 mM (or LN) representing sufficient and severe-limiting N, respectively.
Attempts to correlate DENV DI particle numbers in patients with the severity of symptoms were thwarted, in part, by a lack of sufficient subjects with severe symptoms.
The prescribed dose of Oxycontin, one tablet every twelve hours, is usually sufficient to relieve severe pain.
These results suggest that the collapse of cavitation bubbles is a necessary, but not sufficient, condition for severe cavitation erosion.
The present study confirms these findings by showing that blood flow rates lower than 750 mL/min are not sufficient to correct severe forms of respiratory acidosis.
These lines can meet 16 20 % of the estimated average requirement of Zn, which is sufficient to overcome severe health problems caused by Zn deficiency.
Camargo and colleagues initially observed that YAP1 overexpression is sufficient to cause severe abnormalities in the skin of mice[64], and later reported that YAP is essential for normal skin homeostasis by regulating the epidermal stem cell pool, while MST1/2 are dispensable for normal skin biology[82].
In this study, we show that specific ablation of Shh signaling using the tamoxifen-inducible TNCYFP-CreER line to eliminate Shh pathway activator Smoothened in Bergmann glia is sufficient to cause severe cerebellar hypoplasia and a significant reduction in CGNP proliferation.
Hence, over-expression of Ets1 alone is sufficient to cause severe epidermal dysplasia.
