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Clean-up of extracts was dispensable and standard single quadrupole MS displayed sufficient selectivity and sensitivity.
Despite the logarithmic relationship between peak area responses versus concentrations, sufficient selectivity, precision and accuracy were achieved.
This assay format enabled the specific assay of DHODH activity in biologically complex samples such as cultured cells and tissues, and had sufficient selectivity and sensitivity for measuring the DHODH activity.
Sensor technology demands to design a sensing system having higher sensitivity, sufficient selectivity, fast response time and efficient reproducibility with simple operating and recognition methodology.
Inhibitors of the zinc metalloproteinase have been investigated as potential therapeutic agents, but LF is a challenging target because inhibitors lack sufficient selectivity or possess poor pharmaceutical properties.
Whereas platinum is one of the best electrocatalyst in pure sodium hydroxide, none of the classical electrocatalysts: gold, silver and platinum, exhibit sufficient selectivity towards the ORR.
Similar(39)
Enzymes of central carbon metabolism are essential mediators of Mycobacterium tuberculosis (Mtb) physiology and pathogenicity, but are often perceived to lack sufficient species selectivity to be pursued as potential drug targets.
And no response of Cygnus to the adenosine/IBMX stimulation, inducing cAMP increase detectable by Epac1-camps, was observed, confirming sufficient cGMP selectivity of Cygnus in living cells as well as in vitro (Figure 1C).
As the mechanisms underlying the reversible aggregation of SGs become understood, use of SG modulators, rather than full translational inhibitors, might provide sufficient biochemical selectivity much like gamma-secretase modulators can reduce Aβ production without inhibiting the general function of gamma-secretase [47].
CDXG kinases are conserved in mammals, and these results highlight the liability of kinase inhibitors that lack sufficient host/parasite selectivity.
Accordingly, FK866 and other NAMPT inhibitors did not demonstrate sufficient tumor-selectivity to achieve clinical success as single agents.
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