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Studies on knock-out mice showed the essential and sufficient role of K-RAS, but not N-RAS and H-RAS in embryonic development.
The difference between the high prevalence of diabetic neuropathy compared with the low prevalence of Charcot neuroarthropathy and the different clinical features of the diseases seems to support the hypothesis of a not sufficient role of diabetic neuropathy in the pathogenesis of Charcot neuroarthropathy, with the probable involvement of other factors (i.e., genetics).
Our cyclopamine and transplantation experiments underscore the necessary and sufficient role of MPs and their expression of netrin 1a at the HMS in the ultimate formation of the zebrafish lymphatic system (Figs 2, 3 and see Fig. S1 in the supplementary material).
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In these types of experimentally induced autoimmune model, CNS-resident cells play no necessary or sufficient role in induction of pro-inflammatory autoimmune responses.
Interestingly, expression of rye on a wild type genetic background did not increase sleep: this indicates that rye plays a necessary, but not sufficient, role in generation of sleep.
This is consistent with the early expression of isoform 2 detected by qPCR and its sufficient role in normal development of the hair bundle.
The genetic background plays a fundamental but not sufficient role; smoking is an independent predictor of ILD, and a correlation with the presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies has also been reported.
The unions -- the United Federation of Teachers and the Council of School Supervisors and Administrators -- have feuded with the administration for months, mostly over whether rank-and-file educators had a sufficient role in the mayor's overhaul of the school system and whether their labor contracts are an obstacle to fixing the schools.
This notion has also been applied to humans, in which the early view that social cues have a necessary and sufficient role as circadian time-givers independent of light has reversed and light is now viewed as the primary, if not exclusive, circadian time-giver17,20 time-giver17,20
These results confirm the indirect effect of aerosols, namely aerosols play sufficient role as cloud condensation nuclei (CCN).
The entire framework enables us to obtain a repository of sufficient role-explicit queries from a query log without human intervention.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com