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In cases of inadequate height and width of the maxillary alveolar crest a sufficient recipient site is required.
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C6-sufficient recipients rejected their transplants at an accelerated rate (5 days, n = 6) compared with control animals (7 days, n = 5).
Further, liver disease could be induced by T cell transfer into CD1d-deficient as well as CD1d-sufficient recipients.
The biggest challenge to gene therapy is how to efficiently deliver the desired therapeutic gene into a sufficient number of recipient cells to achieve significant clinical efficacy.
Natural genetic competence renders bacteria able to take up and, in case there is sufficient homology to the recipient's chromosome, integrate exogenously supplied DNA.
This model depends only on innate effector mechanisms, as a cocktail of arthritogenic antibodies transferred into wt recipients is sufficient to induce an inflammatory erosive arthritis even in the absence of a functioning adaptive immune system [ 35, 36].
The ACRE study was based on the assumption that organ donation is of sufficient benefit to organ recipients and to society generally that it is appropriate to test techniques to maximise organ donation consent rates using a study design that required a waiver of consent.
However, a prerequisite for the effectiveness of written discharge instruction is a sufficient literacy level of the recipient.
Indeed, Spiegel et al [31] have recently demonstrated a marked increase in the number of hematopoietic stem cells in the BM of heparanase over-expressing transgenic (Hpa-tg) mice and that a limited dose of WBC from the BM of these mice was sufficient to rescue lethality irradiated recipient mice [31].
Transfer of MBP-specific CD4+ T cells from EAE animals can be sufficient to induce EAE in recipient animals, so long as the transferred cells are activated [ 22].
Transmission of EBOVs from bats and other zoonotic reservoirs to humans requires a hierarchy of enabling conditions that connect the redistribution of reservoir hosts, episodic viral infections within these hosts, random human exposure to infected blood or carcasses from these hosts and sufficient susceptibility of the new recipient human host (Plowright et al. 2015).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com