The presence of a "suitable" protein pocket is necessary but not sufficient to guarantee potent binding of drug-like small molecules.
Thus, the immune-incompetence caused by transient lympho- or leukopenia is not sufficient to inhibit potent antibacterial responses of the host and mechanisms distinct from leukodepletion must account for increased bacterial superinfection during viral defence.
However, such factors are neither required nor sufficient for the potent effect of LIF.
14, 15 Constitutively active derivatives of mDia1 are sufficient to induce potent activation of a MAL/SRF reporter gene.
Of interest, the rest period of 10 s was found to be sufficient to induce potent bone formation in response to low magnitude mechanical loading.
Due to the expression of membrane-bound complement regulatory proteins, complement deposition on neoplastic cells is limited and therefore not sufficient to induce potent tumour cell killing [ 9].
It has been demonstrated that sufficient PPIX, a potent photosensitiser, is synthesised by exogenous ALA administration to produce a photodynamic effect following exposure to light (Kennedy et al, 1990; Fukuda et al, 1993a).
These data demonstrate that in the absence of PD-L1 silencing, as few as 10 activated DCs are sufficient to prime potent CD8+ T cell responses, which can control tumour growth.
Therefore, our results show that the inhibitory effect of SOM230 on CAF secretions is insufficient to affect tumour growth, but is sufficient to provide potent chemosensitization, bypassing pancreatic cancer cell resistance to gemcitabine.
Even though several preclinical efficacy studies [ 28, 62, 63] on resveratrol have reported that very low plasma concentrations of resveratrol (20 nM - 2 μM) are sufficient to exert potent cancer chemotherapeutic efficacy and pharmacodynamic activity, such in vivo levels would be insufficient to induce anti-carcinogenic effects in in vitro studies.
