Another reason to doubt that mesolimbic dopamine release in the ventral striatum is in itself sufficient for pleasure (as many have thought) is that indiscriminate release of dopamine at inappropriate times, letting things grab attention at random, seems to lead to amphetamine psychosis and schizophrenia.
So it appears that it won't do to make either desire or its satisfaction or the sensing of increases in that satisfaction sufficient for pleasure, let alone identical to it, as various philosophers have variously proposed (e.g.; Davis 1981 , 1982 Schroeder 2001, 2004), not even desire for the continuation of one's present experiences (Madell 2002, pp. 97-98).
For similar objections to the effect that excellence of music and of the listener's auditory and musical capacity are neither necessary nor sufficient for the pleasure of listening to music, see Brentano 1921/1969, 26a, p. 156 and 1929/1981, I,iii,5/p.
One argument infers it from the motivational egoist claim that each of us is always motivated to maximize what we take to be our own good, plus the claim that we each accept that our good is our maximal or sufficient balance of pleasure over displeasure.
Formerly a self-sufficient world of pleasure grounds, greenhouses and productive gardens, providing not only beauty but sustenance for the thousand-acre Victorian estate of the Tremayne family who had been at Heligan since the 16th century, the gardens were gradually abandoned after World War I.
This response is underpinned by insistence on the wider thought that any pleasure is sufficient for value.
It abandons altogether the thesis that pleasure is sufficient for value, while also continuing to insist that pleasure is necessary for value.
It distinguishes at least two basic kinds of value, and continues to insist that pleasure is sufficient for one of these, while also accepting the objector's thesis that there is at least one other sort of value for which pleasure is not sufficient.
Consistent with this, but rather concessively, it could also be claimed that pleasure is sufficient for only very little value, and that substantial or major value is present only if further conditions are met.
Mesolimbic dopamine is likely neither necessary for phenomenal true pleasure nor sufficient for either it or for its cognitive awareness, but more plausibly helps organize, stabilize, and sustain activity linking the two, while also otherwise facilitating motivation and learning.
