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Additionally, systemic administration may not lead to local drug concentrations high enough to yield disease modification because of rapid systemic metabolism or lack of sufficient partitioning into the diseased tissue compartment.
Copy number control of plasmids is regulated through self-encoded negative regulation mechanisms using antisense RNA or through repeated genomic sequence elements called iterons in order to retain sufficient partitioning upon host cell division and also to avoid overshooting so that the plasmid can stably co-exist within the host cell without metabolic overload [ 43].
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Custom branded channels may create a sufficient partition from the parts of the site filled with copyrighted content and thus command higher ad prices.
In this paper (Andrew et al., 2011), the group found that the addition of the TM domain of CD40 – which has previously been shown to be required for membrane microdomain localisation of CD40 (Vidalain et al., 2000; Bock and Gulbins, 2003) – was sufficient to partition the resultant ΔGPI-CD40 chimera into membrane microdomains (Andrew et al., 2011).
The results show that neither hydrophobic matching nor palmitoylation is sufficient for partitioning of peptides into Lo phase domains.
We focused our analysis on these two groups because the Hawaii State vegetation map alone does not provide sufficient detail to partition the mapped C results into finer levels of invasion, particularly since the invasion process is ongoing and highly dynamic (in favor of alien invasive species dominance).
Even though binding of U2A′ and SLII is not negatively cooperative, the difference in the free energy of binding cooperativity (ΔΔ g = 3 kcal/mol) between U2A′ and the SLII/SLIV complex binding to SNF is sufficient to effectively partition the U2A′ protein away from the U1 snRNP and into the U2 snRNP, when the concentrations of the various components are found at expected cellular levels.
It has been suggested that small changes in spindle orientation are sufficient to partition A/B components in such divisions [ 1, 2, 19].
Therefore, simple market-based solutions such as partitioning the ecosystem, attributing property rights and applying the polluter-pay-principle are not sufficient for getting a viable strategy.
Partitioning methods.
Figure 2 : Semantic partitioning.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com