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To ensure sufficient oxygenation, oxygen therapy during mechanical ventilation, anesthesia, and resuscitation usually exceeds physiological levels.
The fraction of inspired oxygen (FiO2) was set at 1.0 for the first three hours post-injury and was then adjusted to maintain sufficient oxygenation (arterial oxygen saturation (SaO2) > 95%, partial pressure of arterial oxygen (PaO2) > 90 mmHg) whenever possible.
Both were controlled from post-chamber dissolved oxygen monitoring (DO2), ensuring sufficient oxygenation was afforded to biomass throughout the chamber (11.79 +/− 3.5% (mean +/− SD, n = 15), with a non-toxic concentration to the base of the chamber from the SUB.
Consequently, achieving higher tissue oxygen tension and paO2 is crucial for maintaining sufficient oxygenation of the damaged brain tissue.
However, cerebral oxygenation may serve as an indicator of the sufficiency of systemic circulation and as such help to ensure sufficient oxygenation of other vital organs during the first critical days.
For sufficient oxygenation and nutrition of the tissue-engineered constructs, the distance between each microvessel-like channel in the network should ideally be within 100 200 μm.
Similar(23)
Increasing the plasma oxygen concentration with hyperbaric oxygenation is a potent means of delivering sufficient oxygen to the brain for tissue repair.
In fact, tissue blood flow must be adjusted to ensure sufficient oxygen extraction as capillary dysfunction becomes more severe, thereby changing the normal relationship between tissue oxygenation and blood flow.
We show that as CTH increases, normal vasodilator responses must be attenuated in order to reduce the degree of functional shunting and improve blood-tissue oxygen concentration gradients to allow sufficient myocardial oxygenation.
ECMO provides sufficient extracorporeal oxygenation and removal of carbon dioxide.
In the artificial lung, therefore, while high extracorporeal blood flow is required and low gas flow is sufficient for oxygenation, for CO2 removal very low extracorporeal blood flow is sufficient and high gas flow is required.
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