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Recently, we investigated the cost reduction of mutation testing based on the identification of sufficient mutation operators [28].
We will continuously update it by adding more genomes, as soon as sufficient mutation data will accumulate.
It is also possible that the DNA sequences we examined do not have sufficient mutation rates to have accumulated nucleotide differences in the time since divergence.
Although TALEN-mediated gene knockout is a powerful approach for addressing gene functions in Ciona, constructed TALENs do not always have sufficient mutation activity and therefore another approach that can compensate for inactive TALENs is necessary.
Although there appears to have been little divergence in sequence since the evolution of STS from CHS, there has been sufficient mutation to lead to changes in the products synthesised.
This suggests that either the region is not correctly assembled, or that an ancient breed foundation event may have occurred in which the yellow allele was fixed in this breed, but that sufficient mutation events have occurred on this MC1R haplotype to cause it to fail to be detected as a sweep using the ultra-high-density data.
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In the process of adaptation, bacteria need to accumulate sufficient mutations for challenging new niches.
Improvement in formulation and a more sustained treatment regimen may allow sufficient mutations to accumulate.
In its modern guise, the hypothesis proposes that tumor cells have to accumulate sufficient mutations to become metastatic while the target site has to be permissive to allow the appropriately mutated tumor cell to survive and prosper [5], [6].
It is a reasonable assumption that the viruses, which require a high level of genomic mutations for their evolution and escape but have only a few chances to replicate their genomes by their own polymerases (i.e. HIV-1), might have evolved to harbor highly error-prone polymerases (i.e. HIV-1 RT) to generate sufficient mutations in really limited chances.
The probability of a cancer acquiring sufficient mutations is thus much higher than that in Loeb's calculation, because all the stem cell's progeny in the expanding tumour clone have a chance of acquiring mutations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com