Suggestions(5)
Exact(7)
In its report on Wednesday, the academy acknowledged the initiative's progress, but added that "there has not been sufficient linkage between research and research findings and the creation of strategies to prevent and manage risk".
With sufficient linkage disequilibrium (LD), haplotypes could be used in association studies to map common alleles that might influence the susceptibility to common diseases, as well as for reconstructing the evolution of the genome.
This study identified 9 chromosomes with regions showing sufficient linkage to warrant the genotyping of all offspring.
They could escape GWAS detection because their multiple alleles cannot have sufficient linkage disequilibrium (LD) with bi-allelic markers as the single nucleotide polymorphisms (SNPs) analyzed in GWAS.
Significant markers could potentially represent causative mutations within previously identified genes, functional RNAs or regulatory regions, or more likely are not causative by themselves but in sufficient linkage disequilibrium (LD) to pick up the effect of the nearby causative factor.
For example, larger sample sizes are required when common SNPs explain less variance (i.e., SNP heritability is low), which can be due to, for example, common SNPs being not in sufficient linkage disequilibrium (LD) with the causal variants or total heritability being low.
Similar(53)
Based on the evidence that one of the main failures is the lack of sufficient linkages between the different actors involved in the dynamic of the system, this paper proposes third-generation foresight as an instrument of science and innovation policy for resolving the problem of systemic failures.
This "CO homeostasis" ensures that sufficient linkages between the homologs are generated.
Using a high MPD threshold means that VOI values are most often imputed from the likelihood, indicating that in some situations, standard multiple imputation would be sufficient for linkage.
The catalytic domain of OTULIN (OTULINcat, aa 80 352) is sufficient for linkage specificity, and OTULINcat C129A bound Met1-diUb with a similarly high affinity as full-length OTULIN C129A, as revealed by fluorescence anisotropy measurements (K D 196 versus 178 nM, Figure 1H).
The challenge remains how to optimise the potential benefits of the volunteer cadre in relation to formal CHWs, whilst retaining elements that may be crucial to their impact; the spirit of volunteerism, the community social mobilisation, the focus on household-level prevention and the density (ratio) required for sufficient community linkages to the health system.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com