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So how can we answer such questions in ICU patients in order to reach a sufficient level of evidence?
A systematic review (2015) of six cartilage repair procedures likewise concluded there were poor study methods and a lack of sufficient level of evidence to make a recommendation for any of the procedures [15].
However, we believe seventeen interviews with professionals, seven focus groups with patients and one focus group with health services researchers provided a sufficient level of evidence for an explorative study of this nature.
When the cumulative z curve crosses the trial sequential monitoring boundary, a sufficient level of evidence for the anticipated intervention effect may have been reached and no further trials are needed.
There is currently limited published data that reaches a sufficient level of evidence about the role of ECM scaffolds alone in chronic and difficult-to-heal wounds [ 3, 20– 27].
Other putative markers of endocrine resistance in ER-positive cancers, although supported by strong preclinical data, have not yet achieved a sufficient level of evidence that one should withhold potentially life-saving and beneficial therapy based on their results.
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For patients treated in the ICU, there is no sufficient level of scientific evidence enabling a strong recommendation.
This is the key piece of evidence, and there is already sufficient level of analysis in the paper to support it.
Nevertheless, evidence-based information on a sufficient level of compliance is scarce complicating the interpretation of compliance reports.
Look for a sufficient level of accuracy.
Consequently, any advice remains pragmatic: assess whether the hypothesized benefit was realistic, assess whether statistical power was sufficient, assess the level of evidence of the studies, assess whether the tools to measure and control blood glucose were adequate, assess whether the targets were achieved, and finally assess whether the levels of glycemic control diverged relevantly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com