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Remarkably, both C2A and C2B domains are able to penetrate the membrane with nanomolar affinities, which is a binding energy (∼50 kJ/mol) sufficient for overcoming the energy barrier to lateral rotation of SNARE complex (Fig. 2B).
In contrast, the activation of CREB alone has been shown to be sufficient for overcoming myelin's inhibition of neurite outgrowth [ 13].
An axial scanning speed of 200 Hz is achieved (Fig. 4c), sufficient for overcoming motion artifacts for future in vivo imaging of live tissues.
This result suggests that individual motors can unwind ∼12 bp while multiple motors may cooperate to increase unwinding processivity or generate forces sufficient for overcoming difficult sequences (Eoff and Raney, 2010).
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Unfortunately it's not a sufficient condition for overcoming political or religiously inspired violence, even though it's still a worthy aim.Photo credit: Tony Blair Faith Foundation.
Using a loading dose of clopidogrel rather than small daily doses was not sufficient for adequately overcoming increased platelet reactivity in patients with type-2 diabetes, highlighting the need for more effective anti-platelet drugs for such patients.
The complementary expression patterns of ZmNAS genes indicate maintaining sufficient NA is essential for overcoming fluctuating iron status.
Supplying sufficient oxygen to engineered tissue, has been a major challenge for overcoming the effect of hypoxia.
The key components introduced in this document are the proposed strategies for overcoming the inability to produce compounds in sufficient quantities via the radiosynthetic routes for full chemical characterisation and toxicology testing.
Apparently, the partial constitutive SGK-1 activation that occurs in sgk-1 gf) sgk-1 gf(Jones et al., 2009) is not sufficient to overcomutantsneed for rict-1 in this context.
The use of uncorrected radar estimates leads to substantially underestimated thresholds with respect to the reference scenario; adjusting radar data for bias is not sufficient to overcome this problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com