We did however observe that delivery of CO after the challenge was both necessary and sufficient for efficacy, indicating that prophylaxis may not be a requirement for inhaled CO to be of benefit.
In yeast, Maf1 dephosphorylation is linked to nuclear localization, but nuclear localization is not sufficient for transcription repression, indicating that other signals are necessary to activate the protein [22].
As noted in the Introduction, the FXF sequence has been reported to be sufficient for MAPK binding, indicating that these sites may also bind MAPKs.
This segment of M. luteus Rpf is both necessary and sufficient for biological activity, indicating that it corresponds to a functional protein domain [ 5].
That the NTCs of Toc33 and Toc34 were necessary, but not sufficient, for plastid targeting indicated that other important targeting information existed in the N-terminal regions of these proteins.
Total probability of identity (PID) values for each marker set were calculated to be 5.5×10−18 for Rousettus and 1.5×10−4 for Cynopterus, indicating sufficient power for our analyses (Table S1).
According to WHO guidelines, parasitemia >4% is sufficient to indicate treatment for severe malaria [22].
However, a bacterial system has recently been exploited to co-express model TA proteins with TRC40/Get3 [ 21, 29], and the resulting complexes were shown to be sufficient for facilitating membrane insertion, indicating that TRC40/Get3 acts at a very late stage of TA protein delivery to the ER.
This is because these fusion genes are not sufficient for disease development, as indicated by protracted post-natal latencies, non-concordant phenotypes in monozygotic twins (Wiemels et al., 1999; Wiemels et al., 2002) and the lack of overt leukaemia in transgenic mice (Rhoades et al., 2000).
The cumulative Z curve crossed the trial sequential monitoring boundary for harm, indicating that sufficient evidence exists for a 30% increase in relative risk of severe hypoglycaemia when intensive glycaemic control is targeted (fig 14).
