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These interesting findings could be explained by several hypotheses that are not mutually exclusive: (1) lower levels of HER2 expression may be sufficient for benefit from trastuzumab, (2) small undetectable populations of HER2-overexpressing cells may drive benefit from trastuzumab, and (3) trastuzumab may work through eradication of minimal residual disease by immune-related mechanisms.
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For example, clinical trials are commonly designed to provide high-quality evidence and sufficient power for benefit outcomes.
Dose adaptation of existing medication may be sufficient for further benefit to be judged over the subsequent 1 3 months.
Prebiotics, as well as probiotics doses and types, need to be established to ensure that health benefits are accomplished, so reliable clinical data are needed to determine whether the probiotic counts and prebiotic dose used are sufficient for health benefits.
In a simple environment, this stability was sufficient for the benefits of increased evolvability to be paid off before non-robust types could invade.
Fourth, a relatively high proportion (75%) of our study participants reported levels of physical activity that could be classified as sufficient for health benefits.
No inducement was provided to the participants, but they were informed verbally and in the cover letter that they would be informed if their physical activity level is sufficient for health benefits after completing the study.
The independent national insurance fund would have a responsibility to ensure that contribution rates were sufficient to pay for benefit entitlements over the long-term.
One may argue that a small improvement in the self-binding affinity would be not sufficient for generating visible benefit in the current Drosophila genome.
Here we address the target engagement question: what is the minimum extent of Aβ lowering sufficient for significant cognitive benefit in AD patients?
Here, even smaller numbers of monocytes or macrophages might be sufficient for a clinical benefit as a bridging therapy for infectious diseases or as tissue resident macrophages in organotropic transplantation scenarios (Happle et al, 2014; Lachmann et al, 2014; Suzuki et al, 2014a, b).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com