Sentence examples for sufficient efficacy in from inspiring English sources

Previously, structure-based drug design was used to develop substituted diphenyl ethers with potency against the Mycobacterium tuberculosis (Mtb) enoyl-ACP reductase (InhA), however, the highly lipophilic centroid compound, SB-PT004, lacked sufficient efficacy in the acute murine Mtb infection model.

In summary, rituximab, which improved the outcome of DLBCL patients, did not show sufficient efficacy in EBV-positive DLBCL patients.

Strengthening of the proximal femur following minodronic acid hydrate administration was also verified, indicating sufficient efficacy in the enhancement of bone density.

Despite a strong preclinical rationale and promising preclinical and early phase data, BI 2536 has failed to demonstrate sufficient efficacy in phase II clinical trials to date and development has been discontinued.

While in this sample the improvement of depressive patients treated with olanzapine monotherapy was satisfactory [ 7], olanzapine monotherapy failed to demonstrate sufficient efficacy in a specifically designed clinical trial [ 11].

However, after a review of available evidence in 2009, the WHOPES Working Group decided not to extend WHO full recommendation from 3 to 5 years [ 11], indicating that the evidence could not prove that sufficient efficacy was maintained in the 4th and 5th years.

The goal of this study was to determine if oral administration of a COX-2 inhibitor can inhibit reproductive function with sufficient efficacy to prevent pregnancy in primates.

Although these results were replicated in Fmr1 mutant mice (Dolen et al., 2007; Yan et al., 2005), clinical trials for mGluR antagonists failed to demonstrate sufficient efficacy for some behavioural parameters in human fragile X patients (Jacquemont et al., 2011).

Consequently, the combined dex/CRH test is suggested as a screening tool to decide whether new compounds designed as antidepressants provide sufficient efficacy to normalize corticoid receptor signaling in depressed patients.

Therefore, a sufficient efficacy according to EN 1500 might also be achieved in vivo in an application time shorter than 30 seconds.

Lack of sufficient efficacy is the most common cause of attrition in late-phase drug development.