This combination of factors made it difficult to purify sufficient antifungal compound(s) for analysis and identification.
In DNT test library selection, new approaches are required (Leist et al. 2012a) to break a vicious circle between lack of sufficient tool compounds, and the inability to classically validate test systems without such compounds (Leist et al. 2010, 2012b).
This research is the first to show that self-healing is not simply a requirement of having sufficient healing compounds (e.g. calcium acetate) but that a minimal number of bacterial spores are also required to ensure that sufficient cells take part in the healing process.
Although we acknowledge that our approach has weaknesses concerning the definition of positive controls, it provides nevertheless a new opportunity for breaking a vicious circle between lack of sufficient reference compounds and a paucity of validated assays.
And the reaction doesn't use up or degrade NU-1000, so relatively small quantities are sufficient, and the compound is reusable.
The attainment of acceptable weld properties requires a thin layer of intermetallic compound, sufficient dilution to minimize migration of alloy elements, and avoidance of an excessive heat-affected zone, which would result in softening of the area.
One of the most serious bottlenecks in developing natural products from marine sources during the past decades has been the availability of biomass and/or of optimised cultivation conditions to gain sufficient amounts of compound for preclinical and clinical studies (Raghukumar 2008; Pan et al. 2008; Schulz et al. 2008).
Tsc2+/−Eμ-Myc lymphomas were cultured ex vivo and exposed for various times to a concentration of compound sufficient to completely block global protein synthesis (Fig. S6).
Two SS classes (Table 1) are specified to provide sufficient variety of compound travel paths.
Provided that a sufficient amount of compound is available, the most easily accessible RDCs in carbohydrates are those between the directly attached protons and carbons (D CH ).
