The range of SR of tadpole communities is obviously sufficient to detect patterns, as indicated both in the curvilinear FD curve and the species richness dependent functional redundancy (discussed below).
This is an order-of-magnitude below the IC50 and therefore not by itself sufficient to inhibit elongation, as indicated by the marker in Fig. 2 A. We therefore conclude that the observed inhibition of elongation results from the specific interaction of αB-crystallin with the αSyn seed fibrils.
This is because these fusion genes are not sufficient for disease development, as indicated by protracted post-natal latencies, non-concordant phenotypes in monozygotic twins (Wiemels et al., 1999; Wiemels et al., 2002) and the lack of overt leukaemia in transgenic mice (Rhoades et al., 2000).
Importantly, ectopic expression of miR203 in HC11 and IMEC cells was not sufficient to induce differentiation as indicated by β-casein expression (data not shown), however, it did suppress ΔNp63 α, which lead to induction of the pro-differentiation gene HBP1 (Supplementary Figures 3A and B).
Because of their PNA backbone, Light-up probes are highly specific: a single base mismatch in the target sequence is sufficient to prevent probe binding, as indicated by the lack of fluorescence increase [ 98].
The NCAM/FGFR interplay was not only required but also sufficient for SKOV3 cell invasion, as indicated by the potent pro-invasive effect of the Encamin-C peptide (Fig 4B).
These findings are consistent with our earlier findings (Figs 6 and 7) where we saw that amino acids and sugars were sufficient to maintain insulin/PI3K signaling (as indicated by weak induction of 4ebp and dInR mRNA when larvae were transferred to amino acids/sugar compared to the strong induction seen with complete starvation) yet they failed to maintain mRNA translation.
Alternatively, the level of knockdown of FKBP12 in PC3 cells may not be sufficient to impact mTORC1 signaling, as indicated by the fact that the levels are only lowered to the basal levels of HeLa cells, which are still responsive to mTORC1 inhibition by rapamycin.
However, a positive attitude towards physical activity and the intention to be more physically active [ 19] are not sufficient to ensure actual exercising, as indicated by low attendance rates (e.g., 43-91 % attendance rates; [ 10, 18, 38]) and high dropout rates (e.g., 26 % after three weeks; [ 18]) in prior physical activity intervention programs.
