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Paclitaxel (PTX) is a potent anticancer drug which suffers limitations of extremely low oral bioavailability due to low solubility, rapid metabolism and efflux by P-gp transporters.
The DPSIR (Driver Pressure State Impact Response) framework has been used to identify relevant information in a number of ecosystem contexts but suffers limitations in terms of its definitional clarity and conceptual foundations, which undermine comparability between studies.
Unfortunately, existing literature suffers limitations with respect to the development of decision support approaches and tools that are able to help decision makers in monitoring and controlling public transportation systems, particularly at the occurrence of disturbances.
To date the latter has only been used in the confocal mode [22] [25] and thereby suffers limitations when imaging in depth in brain tissue [26], [27].
These children may develop a level of expertise that allows them to better understand the precise extent to which a video can stand in for an actual person and where it suffers limitations.
Similarly, determination of lean soft tissue mass by DEXA (technically fat-free mass) suffers limitations.
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However, these models suffer limitations (incompleteness and lack of statistical representativity), which can be overcome by model averaging and fusion.
Most of these methods have been derived from cadaver studies, which often suffer limitations in clinical settings.
Among patients who complained of one symptom, 16.7% suffer limitations due to emotional problems.
Every experienced botanist knows that digital photographs suffer limitations compared with conventional scientific specimens.
Patients with degenerative musculoskeletal disorders suffer limitations in their walking ability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com