12.29pm: The Lib Dem leadership has suffered a significant defeat.
"Paul O'Connell suffered a significant hamstring injury and will undergo surgery this week.
After the Paddington disaster, he was said to have suffered a significant personality change.
Earlier this year, for example, he suffered a significant setback representing the telephone company SBC Communications.
Dodge's critics say that, during his tenure, the Party has suffered a significant decline.
In 2009 the UK's education policy directors suffered a significant blow.
Still, Naoshima, like all of Japan, suffered a significant drop in foreign tourism after the disaster.
Unlike other fiscally troubled municipalities, Nassau County has not suffered a significant loss of population, industry or tax base.
Then came the downturn of the UK housing market and we suffered a significant business loss over the first year.
But Thomas and Scalia believed that Hudson was entitled to nothing, because he had not suffered a "significant injury".
PAGE 29 A POLITICAL BLOW -- The Republicans' long-term plan for a permanent majority may have suffered a significant setback.
