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"suffered a major setback" is a correct and usable phrase in written English.
You can use it to describe a situation in which a person or group experiences a major obstacle or challenge that impairs their progress. For example: "Our project suffered a major setback when our main investor suddenly withdrew their funding."
Exact(60)
Egypt's march toward democracy has suffered a major setback.
"Syriza suffered a major setback, there's no denying it.
The company suffered a major setback when it had to recall defective batteries in Fisker cars.
If that goal really was important, we have just suffered a major setback.
The Finnish prime minister, Matti Vanhanen, said the region's vaunted openness had suffered "a major setback and shock".
The change comes eight months after WNEW suffered a major setback when Infinity fired the station's star hosts.
Bath suffered a major setback in the 17th minute when Lipman was felled after an accidental collision.
Donald Trump suffered a major setback in Iowa overnight, as the Republican hopeful came second in the first caucus to Texas junior senator Ted Cruz.
Brazil's space program suffered a major setback when its VLS-1 launcher exploded on the launchpad at its Alcântara facility on August 22, killing 21 engineers and technicians.
Incentives from the Thai government to encourage farmers to plant even more rubber trees suffered a major setback with the Asian financial crisis in 1997 and 1998.
The left parties lost power nationwide, and the Communist Party of India (Marxist) leader, Prakash Karat, admitted his party "suffered a major setback".
More suggestions(15)
encountered a major setback
experienced a major setback
caused a major setback
suffered a major intrusion
suffered a real setback
suffered a major stroke
suffered a rare setback
suffered a major breakdown
suffered a financial setback
suffered a major decline
suffered a significant setback
suffered a major loss
suffered a dramatic setback
suffered a major defeat
suffered a major power
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com