Sentence examples for suffer from mutations from inspiring English sources
Highly polymorphic microsatellite markers could easily suffer from mutations, allelic dropouts, undetectable null alleles [ 43] and genotyping errors [ 20, 43, 44].
A consequence of the Error Threshold is that, if the per-base mutation rate is constant, longer sequences suffer from mutations more than shorter ones, and there exists a maximum length a sequence can sustain above which the accumulation of deleterious mutations cannot be prevented: The Information Threshold (Eigen 1971).
The normal method also suffers from mutation problems.
This method suffers from mutation of long oligonucleotides, and synthesis and purification of both oligonucleotides are costly.
In the formation of a quasispecies, the population minimizes the mutational load by accumulating sequences that have a reduced probability to suffer from deleterious mutations [ 27, 28, 39, 40].
Most of the currently treated HIV-1 protease (HIV-PR) inhibitors have been prone to suffer from the mutations associated drug resistance.
This might be best explained by the fact that it is difficult to detect the negative consequences of inbreeding, when homozygous individuals suffer from lethal mutations early in life and as a result a low number of inbred individuals reaches the reproductive phase (see [ 45, 51] for details).
Most PCA-based gene synthesis methods can suffer from a mutation rate of ~2 to 4 point mutations per 1 2 Kbp of synthetic gene product [ 4, 36- 38].
Cancer cells frequently suffer from increased mutation rates and abnormal karyotypes, indicative of genome instability (reviewed in Vogelstein et al. 2013).
Under independent selection, asexual reproduction was the only reproductive mode where large finite populations would suffer from fixations of mutations.
But, their DNA (mtDNA) suffers from progressive mutations resulting in reduced ATP production, which is thought to run concomitantly with an increase in pro-inflammatory reactive oxygen species (ROS) [ 1, 2].
