Exact(2)
We speculate that physiological conditions exist in these organelles that create a sudden requirement for Mg2+, which can only be met by a high conductance channel.
The sudden requirement for processing large quantities of secretory proteins can be immense and results in over burdening the folding machinery within the ER, leading to accumulation of misfolded proteins and ER stress (Malhotra and Kaufman, 2007; Walter and Ron, 2011; Wang and Kaufman, 2012).
Similar(6)
The sudden and urgent requirement for a modern court, army and bureaucracy in the 19th century strained the revenue system till it broke, and brought in train the constitutional revolution of 1906, the oil concession and, by extension, the modernising autocracy of the Pahlavi dynasty (1925-79) and the 1979 revolution.
"My head was down and I was working, and when I lifted it all of a sudden it seemed a new requirement for writers to move to Brooklyn," says Amanda Stern, a novelist who has lived for the past 10 years in Fort Greene, a fast-gentrifying grid of 19th-century brownstones bordering a park that might be considered the heart of Brooklyn's writing factory.
Operators and their catheterisation laboratory teams need to be experienced and proficient in rapidly responding to a sudden unplanned deterioration and the requirement for complex bailout stenting strategies.
The teleoperating CPS is able to meet sudden and temporary requirements for exploration and rescue tasks in accidents and disasters [2, 3].
That said, there are two potential developments to monitor that would change the outlook: a sudden loosening of requirements for language and criminal background, and the establishment of large units heavily (or almost entirely) populated by foreign volunteers.
The requirement for inverted commas is telling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com