The accumulation of TERRA at telomeres can also interfere with telomere replication, leading to a sudden loss of telomere tracts.
The error-threshold is the error rate of replication above which the sudden onset of the population delocalization from the fittest genotype occurs despite Darwinian selection; i.e., the break down of evolutionary optimization.
On the other hand, the gene copy number immediately doubles upon initiation of DNA replication which results in a sudden increase in the number of DnaA-ATP synthesized per unit time.
That stallers hinder the growth of units of replication (in general) can be seen from the initial, sudden increase of density in the field, when stallers have just been removed.
The sudden change to a more pro-inflammatory state induced by the abrupt return of HIV replication could result in an increased platelet adhesion and inflammatory cell migration into unstable plaque.
Instead, the abrupt and unidirectional switch from slow to fast modes of mtDNA substitution is consistent with the sudden loss of one or a few mitochondrion-specific DNA repair or replication genes.
However, virus replication dynamics and maximum titers may be impaired by a sudden shift to a new cell substrate and may be improved by serial passages of the virus in the new host cell line.
As pointed out by Teng et al. (2000), conventional gene conversion events between critically short telomeres does not provide an easy explanation for the sudden elongation observed at the termini of type II telomeres, whereas rolling circle replication could provide one potential route for rapid elongation.
Simulations show that this replication framework can realistically achieve good latencies, outperform passive caching, and adapt efficiently to sudden changes in object popularity, also known as flash crowds.
In E. coli, only limited sets of growth conditions have been evaluated and IciA and several other replication origin binding proteins may act as a replication inhibitor during nutrient starvation or during sudden changes in growth rate [15].
The replication is meticulous.
