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After this the pain and lameness seemed to decrease and QOL to increase at a slightly higher rate in the treatment group than in the placebo group, so without the sudden exacerbation at week four or with a longer follow-up, a significant difference between treatment group could have been achieved favoring the treatment group.
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Sudden onset exacerbations (exacerbation threshold crossed on the same day the symptoms started) were associated with significantly more respiratory symptoms than gradual onset exacerbations (exacerbation threshold crossed ≥1 day after symptoms started; p<0.001) [ 29].
However, small intravenous bolus doses of sumatriptan (500 μg) or ergotamine (50 μg) provoke a sudden headache exacerbation which is more convincingly due to transitory high blood levels than low levels [17, 36].
If sudden acute exacerbation is perceived in a more extensive area than that of BP (without following any particular innervation or organ area), probably the spinal and supraspinal neuronal systems are already predominantly involved [ 18].
However, patients with sudden onset exacerbations experienced a significantly shorter recovery time than patients with gradual onset exacerbations (p<0.001), which the investigators considered clinically important.
Type 2 brittle asthma is background well-controlled asthma with sudden severe exacerbations.
Risk factors for death from asthma are [ 1]: 1. Past history of sudden severe exacerbations.
On the other hand, massive exposure to common allergens, sensitivity to nonsteroidal anti-inflammatory agents, and sensitivity to food allergens and sulphites are mainly considered the triggers in sudden asthma exacerbations.
For example, says Dr. Michael Baum, emeritus professor of surgery at University College London, there is a report of eight men with advanced testicular cancer who had surgery to remove the tumors, followed by "a sudden and dramatic exacerbation of the disease".
Because of severe dyspnea, intubation was performed, which caused sudden and unexpected exacerbation of the condition.
Exacerbations with sudden onset are associated with increased respiratory symptoms but reduced exacerbation recovery times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com