Once this sudden brain dysfunction occurs, it multiplies the chances of dying.
This positive inotropic effect was followed by a sudden cardiac dysfunction with increasing diastolic pressure and transient loss of function, from which the majority of hearts recovered spontaneously within 1 min (see Supplementary material online, Figure S4A ).
Typically, non-compaction involves the apical portion of the LV and predisposes to thromboemboli, arrhythmias, sudden death, ventricular dysfunction and heart failure.
Clinical findings oscillate from asymptomatic to congestive heart failure, arrhythmias, valvular dysfunction and sudden death, which cause a mortality of 40%.
We subsequently identified several families of anticocaine catalytic antibodies and found that the most potent antibody possessed sufficient activity to block cocaine-induced reinforcement, organ dysfunction and sudden death in rodent models of addiction, toxicity and overdose, respectively.
Mutations in MYBPC3 can cause hypertrophic cardiomyopathy that is characterized by cardiac hypertrophy, myocyte disarray, contractile dysfunction and sudden death.
Several observational studies have demonstrated an association between moderate kidney dysfunction and sudden cardiac death in people with cardiovascular disease [ 21– 23].
The antimetabolite 5-fluorouracil (5-FU) has been shown to cause angina-like chest pain and, in rare cases, myocardial infarction, arrhythmias, LV dysfunction, and sudden death [ 46– 46].
As the disease progresses with age, patients develop atrial fibrillation, progressive conduction block and left ventricular dysfunction, and sudden cardiac death due to life-threatening ventricular tachyarrhythmias [ 7, 12, 15].
What my family didn't know at the time, because the doctors did not tell us, was that this frightening transformation was a classic case of hospital delirium — a brain dysfunction characterized by sudden confusion and inattention.
Fiercely conjured as well is the sudden tumble in dislocation and dysfunction that the young Ms. Hamilton and her 17-year-old brother, Simon, experienced in the wake of their parents' breakup, when they were left alone in the house to fend for themselves for a summer.
