The primary outcomes were duration of respiratory support, chronic lung disease, length of hospital stay and time to full suck feeds.
Further trials are required to determine if use of HFNC for weaning can reduce the duration of pressure support or reduce time to full suck feeds.
The primary aim of a larger trial will be to determine the optimal method for weaning infants born <30 weeks gestation from NCPAP to reduce duration of respiratory support and time to full suck feeds.
Use of HFNC may be an efficient method for weaning infants from NCPAP even though it did not reduce the overall duration of respiratory support, days to full suck feeds or duration of hospital stay.
There were no significant differences between groups in days of pressure support, cGA off pressure support, cGA off respiratory support, cGA at full suck feeds, cGA at hospital discharge and days of caffeine use.
None of the strategies resulted in a significant effect on the prespecified primary outcomes including incidence of CLD, duration of respiratory support, days to full suck feeds or hospital stay although the study is underpowered to find a difference.
No significant difference was found between groups for primary outcomes including CLD, respiratory support days, days to full suck feeds and days of hospital stay from randomisation (Table 2).
Group 3 had a significantly increased duration on HFNC compared to group 1. Use of high flow nasal cannula may be effective at weaning infants from NCPAP but did not reduce duration of respiratory support or time to full suck feeds.
Primary outcomes were 1) chronic lung disease (CLD) defined as respiratory support or oxygen at 36 weeks' corrected gestational age (cGA); 2) days respiratory support (NCPAP or HFNC or oxygen); 3) days of hospital stay; and 4) days to achieve full suck feeds.
There were no significant differences in days of pressure support, cGA off pressure support, cGA off respiratory support, cGA at full suck feeds and cGA at hospital discharge.> -wrap-foot> * not applicable No significant difference in primary outcomes was found between infants allocated abrupt wean versus gradual wean (Table 4).
Those with a piercing-sucking feeding behavior such as mosquitoes (or other blood-feeding dipterans) and ticks are especially significant for vertebrate viruses, and likewise aphids, white flies and other sap-feeding bugs are consequential for plant viruses.
