Your English writing platform
Discover LudwigExact(60)
Recent evidence has demonstrated that such transcripts control transcription initiation of stable mRNAs by RNA polymerase II using different mechanisms [14], [15], [16], [17].
The majority of eukaryotic genes can produce different transcripts due to alternative splicing or transcription initiation, and many such transcripts encode different protein isoforms.
Such transcripts could be targets of regulation at both promoter escape and transcriptional termination.
A significant fraction of such transcripts appears to arise from intrinsic bidirectional preinitiation complex formation directed by transcription factors bound upstream of active Pol II promoters [ 34, 44].
Protein expression vectors designed for large-scale protein production often include one or more specific tags to such transcripts, to simplify the purification of the targeted protein.
Therefore, we cannot verify such transcripts unless an amplification-free technology is employed.
Also, the use of different gene names to address such transcripts compounds the problem of their identification.
Two transcripts with same TSS were considered as the same transcript and TPs composed of such transcripts were discarded.
This allows such transcripts to be included in the normal analysis scheme, but their calculated fold change will be entirely artificial.
RNA purified at four time-points during the growth phase of the bacterium allowed us to define the temporal expression of such transcripts.
For example, the significant enrichment of mRNAs that were present in the semi-soluble protein fractions that we isolated may have masked the identification of such transcripts.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com