Much depends on the ability of the genotyping method to detect weak second or third alleles.
Such second acts are rare in rock.
After discarding the selected alleles and already assigned reads, second alleles are selected accordingly.
Such "additional" alleles, so-called second-site modifiers, may exert an aggravating effect in an epistatic way and contribute to early and severe disease expression.
Second, conventional sequencing approaches lack sensitivity for the detection of such rare alleles.
These results may suggest that gastric cancer cases with such rare alleles have a bad prognosis.
Is it possible to miss such rare alleles using the existing tagging SNPs?
As such, these alleles are highly suited for cell biology.
Since the first wave of GWAS to search for such alleles, 22 loci have been reported to significantly associate with breast cancer risk by 16 studies [ 31- 34].
Such alleles may produce FMRP, although at lower levels than low repeat alleles, presumably due to translation inefficiency.
