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However, such mutants often exhibit pleiotropic growth defects.
To overcome this problem, an alternative plan for obtaining such mutants was considered.
Two such mutants were subsequently shown to be ruvA and ruvB mutants.
Such mutants are of great interest in overcoming the increasing danger of antibiotic resistance.
Generation of such mutants could pave the way for better anthrax vaccines with longer shelf life.
The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.
Such mutants, if they showed the desired catalytic and pharmacokinetic properties, could be used as catalytic scavengers.
That a bacterium can spontaneously evolve into a new version that can resist our arsenal of antibiotics doesn't seem to bother people as much as the possibility that we can now manufacture such mutants.
Particular attention has attracted the ability of several such mutants to actively promote the development of aggressive and metastatic tumors in vivo.
However, such mutants have not been isolated, and the creation of intended plants by T-DNA insertion has not been possible because a disruption mutant of OsIRE1 is not available.
Such mutants fall into six complementation groups: TUB1, TUB2 and TUB3, the three tubulin genes of yeast, and three new genes, which we have named CIN1, CIN2 and CIN4.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com