Potential explanations for these geographic differences in clinical manifestations include host factors such as rates of diabetes mellitus, alcoholism, access to healthcare, and socioeconomic factors.
One such subtype is hyperactive delirium, of which the manifestations include agitation, hypervigilance, irritability, lack of concentration, and perseveration.
Non-neurological manifestations include re-entrant atrio-ventricular tachycardias such as Wolff Parkinson–White syndrome and multiple lipomas especially in the cervical region.
Bleeding manifestations include spontaneous bruising, epistaxis, menorrhagia, and prolonged oozing after trauma or minor surgery such as a tooth extraction [43].
Other extraskeletal manifestations include hearing loss, dentinogenesis imperfecta, blue/gray sclerae, hypercalciuria, aortic root dilatation, and neurologic conditions such as macrocephaly, hydrocephalus, and basilar invagination.
More characteristic symptoms, such as hemorrhagic manifestations including vomiting of blood, nosebleed, bloody or tarry stool, and bleeding from injection sites, as well as a characteristic rash, appear later in the disease course, and are only obvious in about half of all patients.
Clinical manifestations include prolonged gastroenteritis.
The variable clinical manifestations include swelling, pain, and ecchymosis.
Primary manifestations include pneumonia, hepatitis, and fever of unknown origin.
