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While MAPK-substrate docking is well established as a viable mechanism for bringing MAPKs and substrates into close proximity the molecular details of how such docking promotes phosphorylation is an unresolved issue.
The -box is the module that affords such docking for Ire1, but it can be substituted by an alternative means that provides an mRNA docking platform.
Such docking experiments are, however, subjective, and larger rearrangements of domains often involve tightly coupled motions between smaller regions of the protein, which cannot be traced or understood with the rigid block approach.
We speculated that the Baz patch may provide a docking site for the centrosome to correctly orient and that once such docking occurs, GSCs may interpret this docking as 'correct centrosome orientation'.
But it is rather a question of time than feasibility until research on frozen-hydrated cells will show such docking and fusion events at convenient resolution and in their cellular context.
However, P-body numbers were significantly reduced in non-stressed cells possessing FGs and/or FAs (see below) and in those that retained P-bodies no such docking was evident between P-bodies and FAs (Fig. 1J, compare insets in this figure and in Supplementary Material, Fig. S3B).
Similar(53)
One such dock floats up or down guided by walls of sheet-steel piling driven to bedrock, which serves to anchor or moor the whole assemblage.
Dock: Found on Agate Beach, Oregon Distance travelled 7,280km Beached yesterday, the 66ft pontoon from Misawa, made of concrete and steel but filled with styrofoam, is one of four such docks that broke loose during the tsunami.
The wiDock is one such dock.
Here's another such dock, the Pure-Fi Express Plus from Logitech.
To be fair, it's the first such dock to offer an omnidirectional speaker.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com