But his underlying pleasantness was key to the huge success of his stand-up act, which – even when dealing with darker material such as addiction or divorce – relied more on verbal virtuosity than vitriol.
Carhart-Harris believes that people suffering from other mental disorders characterized by excessively rigid patterns of thinking, such as addiction and obsessive-compulsive disorder, could benefit from psychedelics, which "disrupt stereotyped patterns of thought and behavior".
In the case of Glasshouse, the play deals with the pressures of modern life on the family, as well as issues such as addiction and the vagaries of the current benefits system.
Similar implants in people might one day offer patients a way to activate their own neurotransmitters to alleviate pain, epileptic seizures, Parkinson's tremors, and disorders such as addiction and depression, without employing drugs, electroshock, or the removal of brain tissue.
Hardline Republicans suddenly realised prisons had become profligate symbols of state failure and, to the delight of experts and liberals, shifted resources into tackling underlying causes of crime such as addiction, chaotic backgrounds, inadequate education and mental health issues.
Accept that reality, and you have some hope of controlling these vices, and combatting the worst side-effects such as addiction and crime, while bringing in new revenues for impecunious state governments.
Highlighting how unresolved challenges from childhood can lead to issues such as addiction, suicide and homelessness in adolescence and adulthood, William said: "While the circumstances of any one situation are unique, it is clear that many families could have been helped if they had found it easier to talk openly about mental health challenges in the home".
But corporate takeovers of GP practices are likely to accelerate as private companies win contracts to provide specialist services that are currently provided by GPs such as addiction treatment and minor surgery, cutting GP practice income and threatening their financial viability.
"Onward's singular mission is to cure complex behavioral health issues such as addiction," he said.
Similarly, serotonin levels are linked to disorders such as addiction and depression.
Quality practices and policies yield better program outcomes, which generate improved client-level outcomes in at least one area such as addiction treatment, correctional programming, and HIV care.
