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In human, such a repression has also been reported in PBMCs infected by bacterial LPS and diverse killed bacteria [ 33].
However, in the light of progressive PD such a repression of TH would be disadvantageous, because DA production will be further limited.
To determine if such a repression of gene expression is reversible, cells were treated for 12 h at 300 μmol photons m-2 s-1 and then transferred to 100 μmol photons m-2 s-1 for 24 h.
Therefore, the reason for the insufficient induction of d-xylose to the araD-araA1-ptk here could be that d-xylose is not enough to release such a repression of AraR on the gene set araD-araA1-ptk.
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These observations indicated that bukII of C. acetobutylicum is a glucose-repressive gene and moreover, such a glucose repression is under CcpA-dependent control.
In hypoxia, such a TRAIL repression was removed and an increase of TRAIL expression was induced.
As our results demonstrate, DHEA administration is able to prevent such a transcriptional repression of the immune response.
Such a transcriptional repression via binding of the coding sequence of target genes has already been observed for other regulatory proteins and two-component system regulators, for example, OxyR (Zheng et al. 2001) and PrrA (Eraso et al. 2008).
Although such an irreversible repression of host SAMS activity in the presence of bacteria has not been previously reported in dinoflagellates, a possible, albeit speculative, explanation for our result is that bacterial effectors employ a mechanism that "transiently" down-regulates the transcription of Alexandrium SAMS.
At the time, the Ergenekon prosecutions made a certain sense: in Turkey, the secular élite and its allies in the military had such a history of repression that much of the world seemed prepared to believe Erdoğan, or at least to give him the benefit of the doubt.
The irony that ISIS opened the doors of such a symbol of repression in Syria is not lost on Nadim Houry, the Human Rights Watch deputy director for the Middle East and North Africa.
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