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Such a latent defect would explain why directed evolution of Rv2911 using the less-stringent C-terminal folding reporter GFP produced a variant of Rv2911 capable of folding under more permissive expression conditions (27°C), but incapable of folding productively under more stringent conditions (37°C).
The oncogenic Epstein-Barr virus (EBV) establishes such a latent infection in human B cells [ 1].
This relation is still elusive, but our results suggest that combining the evolutionary and secondary structural information could be crucial to elucidate such a latent link.
But, how can such a latent reservoir be established in light of the intrinsic resistance of resting CD4+ T lymphocytes to the early phase of HIV-1 infection?
Such a latent niche drives formation of a germline tumor, perhaps because its geometry interferes with the movement of GSC progeny out of the niche.
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In a second-order model, some latent variables are made of multiple dimensions and every single dimension can be measured by indicators such as a latent variable.
For the repeated administration of the same items to a sample over different occasions, Anderson (1985) introduced a multidimensional Rasch model with a time specific latent score θ it for person i at occasion t, such that, a latent linear score can be defined as η ijt = θ it − b j. (2).
Hence, enzyme recruitment can be facilitated by any mutation that amplifies the cellular concentration of a catalyst to an extent such that a latent function rises to a physiologically relevant level.
For example, in constructing an Index, indicators that co-vary do not necessarily increase the amount of information in the Index (though in some instances, such as a latent variable construct, they may).
Although bacterial infection was not detected in our two patients, a subclinical Gram-negative infection (such as a latent cyst infection) could possibly have contributed to the pathogenesis of MPO-ANCA-associated CrGN.
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