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An implementation of such a comparator using MOS PLAs is discussed.
We dropped the original "no intervention" as we realised that none of the clinical study reports had such a comparator, only placebo.
In fact, it is almost inevitable to refer to such a comparator in order to imagine possible consequences desired or to be avoided.
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In contrast, the convergence of the HAD-D cut points with the range reported for psychiatric interview would appear to make this scale a useful indicator of a clinical depression and as such a baseline comparator for other scales, as illustrated with the CES-D13 in this study.
However to be able to assert this alternative hypothesis, it is necessary to have tested rofecoxib separately against each comparator and for such a meta-analysis the comparators cannot be pooled.
Full gene screens of BRCA 1 and BRCA2 using a comparator method such as Sanger DNA sequencing would not have been practical due to limitations such as the time required to develop an assay for DNA extracted from FFPE tumour tissue, and the amount of DNA that would have been required to carry out complete screens of both BRCA1 and BRCA2.
I imagine some of it might work for trial interventions where you have a clear comparator - e.g. differentiate the intervention from usual practice (our 'intervention' is the work now and we do not really have a comparator as such).
A random sequence is generated by amplifying a random noise source such as thermal noise digitized by a comparator.
However, the size of the problem is difficult to assess without a comparator group – and such a group is difficult to study, with the limited means of a patient association.
Adopting a comparator may be considered such an influence.
Some debate exists in the literature about whether the use of a placebo treatment as a comparator for complex interventions such as physiotherapy is appropriate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com