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Taking that into account, when new active treatments become successively available, as is the case for mRCC, it will be very difficult to demonstrate any OS gain for one specific treatment even if this gain does exist.
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13 And its very terms show they were used in explicit contemplation of the procedures and machinery then existing under the Railway Labor Act and with the intent of making their exhaustion conditions for securing injunctive relief, not singly or alternatively, but conjunctively or successively, when available.
The non-linear decline pattern of MUP frequency, first slow and later on steep, suggests successively exhausting available MUs' reserves, resulting in lower firing frequencies and failing recruitment.
On smooth adaptive landscapes with only a single peak, locating the fittest solution, or global optimum, is a matter of successively substituting the largest available beneficial mutations.
Tools may be successively adapted according to medications available in the country investigated and revalidated in the new setting.
When several medical therapeutics are tried for one patient, it usually reflects an aggressive tumor, uncontrolled and/or symptomatic, and available therapies are successively attempted to relieve recurrent patient symptoms.
As the level of information available is decreased by successively removing data on numbers at risk and number of events, the ME and the reproducibility standard deviation remain unaltered.
Consequentially, solutions of the pricing problem are added successively until these correcting variables are all available.
For the OSA switching policy, we use the common random sensing model in which the channels are sensed successively in a random order until an available channel is found.
A subject-specific geometry available in literature, three abstractions (which successively diminished in geometric detail) derived from it, and a widely used quasi two-dimensional VF model geometry were used to create computational models.
For sake of generality, work and heat interactions are considered occurring either successively or simultaneously, and both result from generalized available energy of a simple system as defined by Gyftopoulos and Beretta[1].
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