The first method is based on a combination of respiratory flow and electrocardiogram recordings and determines the relative phases of R waves between successive onsets of inspiration.
Using brief intermittent presentations, rivalry dominance shows strong biases such that the same target is perceived with each successive stimulus onset.
Serial correlation analysis of the intervals between successive activity onsets [23] [25] indicated that the ultradian activity bouts were not generated by an oscillatory mechanism (serial correlation coefficients were 0.030±0.05 in WT and 0.128±0.083 in Vipr2−/− mice).
One of the authors (WR) and another participant (AD), who was naïve as to the experimental purpose, completed runs of trials with delays between successive visual stream onsets set to 33, 100, 133, 166, 200 or to 233 ms. A further five participants, also naïve as to the experimental purpose, completed trial runs with delays between successive visual stream onsets of 166 m.
The clinical serial interval was the number of days between dates of symptom onset of successive cases linked in a transmission chain.
Longer repeat expansions are associated with genetic anticipation (ie, earlier disease onset in successive generations), although the differences in age at onset are not entirely accounted for by repeat length.
Autosomal dominant DKC due to mutations in TERC, which encodes hTR, or TERT can demonstrate disease anticipation with increasing severity and an earlier onset in successive generations [10], [30].
Moreover, three poly I C challenges, each 2 weeks apart, showed that each successive challenge produced acute onset deficits that were progressively more severe and less reversible as the underlying disease progressed [ 32].
Latency and infectious periods can be summed into a single statistic called the generation interval, which measures the interval between disease onset in 2 successive cases.
The incubation period for influenza averages 2 days (range 1 4 days), and the serial interval (the mean interval between onset of illness in 2 successive patients in a chain of transmission) is 2 4 days.
