Given a genome, successive lesions altering the function of the genome's component genes may eventually result in expression of a novel phenotype, e.g. cancer.
The virus infects through skin abrasions, resulting in successive lesions of macular, papular, vesicular, pustular, ulceral, and eschar stages for 2 weeks.
Cells are selected after accumulating successive genetic lesions in oncogenes and tumor suppressor genes, resulting in independence from the normal restraints that regulate growth, proliferation, survival, differentiation and migration [ 1- 5].
The rash most often appears in three successive crops of lesions numbering on average 300 to 400 [ 10].
If one describes cancer differentiation as a pathway with several roadblocks, then mutagenesis would serve as a mechanism of taking those barriers away and step-by-step bringing this cryptic program into action: it manifests itself in outward appearance as successive precancerous tissue lesions (Fig. 1).
NER is initiated by two damage-recognition pathways, transcription-coupled (TC -NER and global genome (GG)-NER, which remove damage in roughly four successive sTC -NER) lesion detection, 2) locandunwindinglobaldamagenomeification, 3) excision of the DNA surroundinGG -NEResion, and finally 4) DNA synthesis and liGG -NERto fill the resulting gap [ 20].
In addition, these E. coli isolates were associated with cellulitis lesions in successive flocks.
Signs of FMD symptoms included elevated body temperature above 40°C for 3 successive days, lameness, vesicular lesions on the snout, and coronary bands on the legs [ 28].
The TTF-1 positivity and the absence of renal lesions on successive PET/CTs confirmed that our patient's carcinoma originated in the thyroid, and not in the kidneys.
The volume of tissue occupied by the lesion between successive pairs of serial sections was calculated from the area measurements and the known distance between the sections (100 µm) and summed to determine the total lesion volume.
A new developing tumor, or a newly metastatic lesion undergoes successive cycles of vigorous expansion and cell death depending upon whether or not it is vascularized, the extent of immunological attack it encounters, in addition to other inchoate factors.
