ChemDIS successfully identified known diseases associated with maleic acid including kidney [13], behavioral and gastrointestinal diseases [33].
The resultant biosensor successfully detected known EDCs of hERβ (BPA, E2, and DPN) at similar or better detection range than an analogous cell-based biosensor, but in a fraction of time.
It is also shown that a 'merged' model (i.e., a merged structure-based and ligand-based model) can successfully identify known AIs and differentiate between active and inactive inhibitors.
In application to two collections of yeast mutant data [10], [11], we show that our method successfully identifies known modules.
We demonstrated that the hit rate calculated for 21 binding sites using our approach correlates with the hit rate measured experimentally from NMR-based screening method, and that the method could successfully distinguish known druggable and non-druggable targets.
We successfully predicted known miRNAs in A. thaliana and G. max using our method.
Using the CQ method, we successfully identified known Y sequences from Homo sapiens and Drosophila melanogaster.
They successfully identified known simple and complex regulatory circuits and discovered many putative circuits.
We have demonstrated that conserved co-expression networks can successfully recover known meiotic genes.
