It was concluded that the VHBP method was successfully extended for application to saturated, unsaturated, rigid and deformable porous media.
Our approach has been successfully validated by application to an external test set of 22 alanine mutations in the interface of Ras/RalGDS and outperformed the widely used CC/PBSA, FoldX, and Robetta methods [1].
A series of pilot studies have already evidenced the successfully application of this imaging technique, both ex vivo [ 10, 13, 27– 29] and in vivo [ 30], to reveal the stage of degraded cartilage by quantitatively evaluating the distribution and content of sGAG in murine and rabbit models with knee OA.
This was achieved through three objectives – 1. identifying an optimal method of presenting risk data, 2. designing and building a risk application, and 3. testing the ability of the application to successfully modify patients perceived risk of cancer.
Chiral bis organoaluminum) Lewis acids have been newly designed and synthetic utility of their eminent activation ability of an ether functionality has been successfully demonstrated by the application to asymmetric Claisen rearrangement of allyl vinyl ethers.
The merged beam technique has successfully been developed for the application to neutral reactions.
By using an algorithm based on the Akaike Information Criterion the time-of-flight of the Lamb modes was determined, allowing their threshold detection capabilities for the studied application to be successfully benchmarked.
ECC can be successfully prevented by fluoride varnish application to the teeth of children, and the engagement of the mother through the provision of dental care during pregnancy together with anticipatory guidance and motivational interviewing.
Although SDREM was successfully applied to model organisms, the application to human disease remained a challenge.
Having many successfully applications in the study of biochemical systems [ 27, 43], sensitivity analysis provides a systematic framework to investigate how changes of a parameter cause changes of the dynamic behavior of a pathway, and which parameters are the most crucial ones impacting the whole system.
