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Our conservation-free promoter sets appear to be either too long or too few for de novo discovery, which was successful only on the combined-conservation set, and for 18/20 of the TFs for which we discovered de novo DNA-binding motifs, including the validated BCL6, the top motifs were selected from the combined-conservation set analysis.
These approaches, however, are successful only on rare cases where the system is well constrained and the training data is sufficiently large.
All these approaches, however, have limitations: cross-breeding and back-crossing require the keeping of separate populations, and result in a loss of broodiness in the offspring and may reduce the consumer appeal of the eggs and meat; further within-line selection is successful only on a relatively large scale and under well-controlled conditions.
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After halftime, the Chargers, the most efficient team in the N.F.L. at converting third downs, were successful only once, on seven chances.
A few years ago, intrapreneurially mentorship was the trendy go-to PowerPoint slide for the next big transformative behavior in organizational design, but that format even when successful only encourages 1-on-1 and does little to encourage group collaboration and silos breaking.
Though, in this trial, the treatments were successful on only one of the two patients.
"The fostering agency is successful only because I pass on the things, many of them very nuanced, that my children have taught me about therapeutic parenting," she says.
In the other corner, the authors of "Made by Hong Kong" (also Oxford University Press, £20), who come from the Massachusetts Institute of Technology, retort that Hong Kong will stay successful only if it holds on to its manufacturing prowess and takes manufacturing up-market into high-tech products.It was manufacturing that made Hong Kong's fortune.
All neuroblastoma cell lines tested in the study by Huang et al. [ 127] were sensitive to treatment with BMS-536924 (IC50 range: 0.136-0.277 μmol/L), a specific inhibitor of IGF-1R, but the treatment seems to be successful only when the receptor is on the critical path of the pathogenesis and tumour progression.
We believe that cooperation on issues such as nonproliferation, Iran or trade will be successful only if our relationship is based on trust.
They have been successful not only on the track, but also off it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com