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Since longevity is assumed to be determined by many genes with small effects it could be a successful method to identify novel longevity loci.
Moreover, that k-mer enrichment in the vicinity of exon boundaries is a successful method to identify new splicing motifs, supports the supposition that the codon trends that we observe reflect splice-related motifs (Lim et al. 2011).
Peptide and protein libraries on filamentous phages, in combination with effective selection strategies, have proven to be a rapid and successful method to identify proteins with specific binding properties.
Comparative genomic analysis has been demonstrated as a successful method to identify evolutionarily conserved regulatory elements that direct cell/tissue-specific gene expression (Marshall et al., 1994; Aparicio et al., 1995; de la Calle-Mustienes et al., 2005; Fisher et al., 2006; Prabhakar et al., 2006; Pennacchio et al., 2007; Emerson and Cepko, 2011).
Starting with the proof of existence by purification of the lac repressor protein by Wally Gilbert, using radioligand binding measured by equilibrium dialysis as an assay (39), radioligand binding quickly became a successful method to identify receptors for hormones and neurotransmitters.
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WGCNA has proven successful as an unsupervised method to identify clusters of highly coexpressed genes and relating them to external traits.
Genome-wide linkage analysis is the traditional method to identify QTL and has been successful in mapping major QTL.
Ethical Electric, on the other hand, uses a highly-targeted, strategic method to identify its potential customers.
That study also reported that the present genomic approach is at least as successful as other competing methods to identify QTL.
We demonstrate a successful approach to combine computational and experimental methods to identify expected ncRNAs in a highly divergent protist genome.
We conclude that it is possible to significantly increase access to HIV testing and HAART within a defined geographical area through the use of QI methods to identify and spread successful, locally tested changes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com