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The previous confirmative study in Japan did not have a successful efficacy result [ 25].
This trial tested the effectiveness of the intervention in a representative group of homes and followed a successful efficacy trial.
Two trained gerontology nurses, one at each site, delivered the promoting independence in residential care (PIRC) intervention on the basis of a successful efficacy trial.
This follows a successful efficacy trial, which suggested that an intervention based on activities that are meaningful to the individual person can be effective in improving quality of life for elderly people in residential care.
Two other phase-III adjuvant breast cancer trials, BETH and BEATRICE (Cameron et al, 2013; Slamon et al, 2013), have been negative, highlighting the limitations of bevacizumab for breast cancer in the absence of a successful efficacy marker.
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Though successful, the efficacy of vaccines has been compromised by the unpredictable outbreaks of more virulent field strains.
Indeed, interventions in many health fields that have been found to be successful in efficacy studies have proved impractical to implement in applied settings that have limited time, few resources, and many competing demands [ 14, 15].
Successful in vivo efficacy testing of prodrug has been accomplished by demonstrating the suppression of a retroviral infection of Friend leukemia virus in mice.
A decade after the target discovery, only a few drug candidates have entered the early phases of clinical trials and no successful demonstration of efficacy has been reported in human trials.
In the case of MRSA-related VAP, silver coated endotracheal tubes that purportedly prevent VAP or lymphostatin, which is used to prevent patient colonization by MRSA, may find roles in the critical care setting pending successful demonstration of efficacy in clinical trials [ 23, 24].
RTS,S recently completed a successful pivotal Phase III safety, efficacy and immunogenicity study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com