Successful activation or deactivation was fed back by an action of the animated cartoon figure (i.e. a pole vaulting mouse) and rewarded by points.
Moreover, the degree of left M1 deactivation during successful stopping was proportional to activation of the left striatum (Fig. 4A).
In addition, striatum activation was proportional to the degree of left M1 deactivation during successful stopping, implicating the striatum in response suppression.
Given that MTL regions, including the hippocampus, may be substantially active at rest (Stark and Squire, 2001), a relative deactivation for successful source trials may reflect modification of the tonically active signal in a manner that benefits subsequent source recollection.
First, it may reflect suppression of response-related M1 activation, as striatum activation and M1 deactivation co-occur with successful stopping [7], [8].
This result indicates that stronger activation of the left ventral putamen during successful stopping was associated with stronger deactivation of left M1.
We observed activation of the striatum and deactivation of left M1 during successful versus unsuccessful stopping.
We observed bilateral activation of the striatum and deactivation of left M1 during successful versus unsuccessful stopping (Fig. 3A), in line with previous reports [7], [8], [9], [10], [11].
We therefore performed a PPI analysis and found that activation of the left ventral putamen (-20 8 -4) during successful stopping was proportional to the level of deactivation in left M1 (Fig. 4A, Table S2).
Decreased activation in temporal and supplementary motor areas in response to erotic stimuli in the blocked design could be related to deactivation of "irrelevant" sensory systems and the successful suppression of motor-related actions such as erection responses [ 44].
The co-occurrence of left M1 deactivation and bilateral activation of the striatum during successful versus unsuccessful stopping (Fig. 3A) does not necessarily mean that activation of the striatum is linked to deactivation of M1.
