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One of the most successful continuum models in terms of accuracy and applicability is the CPCM model based on the COSMO [17].
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Continuum models at macroscopic scale.
Continuum models at macroscopic scale. .
Continuum models are based on continuum mechanics and allow the coupling of mechanical, hydraulic and thermo-mechanical behaviour.
Limitations of applications of continuum models are also discussed.
We then derive compatible classic continuum models.
The comparisons of semi-continuum, classical continuum and nonlocal continuum models show good agreement unless the thickness is too small.
Hybrid multi-cell models combine discrete representations of individual tumor cells with continuum representations of diffusible chemicals [70] [74] and either discrete or continuum models of the surrounding tissue.
But the continuum models are in fact worth to study.
Authors' response: Hybrid models can be analogous to continuum models described by reaction-diffusion equations.
Furthermore, global observations in continuum models represent averaged values [ 24] and assume homogeneity of system components.
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