Although these studies, together with early studies of individual disease proteins [ 29- 36], have achieved remarkable successes, large-scale predictions and mechanistic explanations of disease-related complex still remain an open question.
While small projects have 70% chances of success, large projects virtually have no chance of meeting the quadruple constraints.
For success large, well phenotyped case cohorts are required, and international collaborations are essential.
In the wake of Queen's success, large-scale pop-videos became obligatory, with Australian-born film-maker Russeleadingahy leading the new wave of directors able to bring big-screen glamour to the likes of Ultravox and Duran Duran.
Larger individuals are at less risk of desiccation and predation in terrestrial environments [ 12], are able to more efficiently capture terrestrial food, have higher mating success, larger clutch sizes and generally higher fecundity than smaller individuals [ 24, 40].
Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs.
Both Rick and Peter credit their successes, in large part, to effective partnership building and creating financially sustainable programs -- no easy feat.
Because I firmly believe that America's success in large part depends on your success.
Arsenal's ongoing success attracted larger and larger crowds.
After numerous preclinical studies demonstrated consistent success in large and small animal models, gene therapy has finally seen initial signs of clinically meaningful success.
