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While The Sorcerer won critical acclaim, it did not duplicate the success of Trial by Jury.
After the success of Trial by Jury, Gilbert and Sullivan were suddenly in demand to write more operas together.
The success of Trial by Jury spurred several attempts to reunite Gilbert and Sullivan, but difficulties arose.
The success of Trial by Jury launched the famous series of 13 collaborative works between Gilbert and Sullivan that came to be known as the Savoy Operas.
After the success of Trial by Jury, there were discussions towards reviving Thespis, but Gilbert and Sullivan were not able to agree on terms with Carte and his backers.
The success of trial registries depends on a number of factors.
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Since it is impossible to determine precisely how RCTs communicate, we assume that RCT interactions could be formed in three ways: (1) based on shared characteristics between trials, (2) based on the treatment success of trials, and (3) at random.
The reasons for trial failures suggest means of enhancing the success of trials, including improved rating strategies, enhanced training, and better patient-selection approaches [ 16, 17].
The inherent heterogeneity of lupus patients and the difficulty in clearly defining a meaningful and quantifiable clinical outcome are limiting the success of trials of promising and rationally designed biologics.
In this regard, CSOs reported that 'having a desk' within a clinical team and regularly attending meetings enabled development of trust and a sense of shared responsibility for the success of trials.
The future success of trials evaluating CDK4/6 inhibitors in CRPC is likely to hinge on enrichment with patients whose tumours exhibit cyclin/CDK activation in the background of intact RB1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com