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The success of binding of anti-peptide antibodies to native protein has been attributed to many structural properties and includes secondary structure, hydrophilicity and surface exposure of protein binding sites; however, the contribution of any individual parameter or a combination that can assure an antigenic response is currently unknown[22], [23], [38], [39].
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While our rescoring method leads to significant improvements of the final success rates of binding site predictions, performance of the classifier itself is less satisfactory (see Table 2).
In the case of FAD, the success rate of binding conformations (black part of the bar in Fig. 2A and B) was relatively low.
The EU has been a great success in terms of binding Europe together economically, reducing trade barriers and embracing a common currency.
The original success of the heparin-antithrombin binding model, however, is becoming somewhat tempered by the recognition that the presence of distinct protein-specific saccharide sequences is more likely the exception than the rule [3], [5], [9], [12].
The main key to success in structure-based drug discovery is the accurate prediction of binding affinities of hit compounds.
The success of PCR amplification relies on the binding specificity; that is, a primer anneals to its target sequences.
The success of such selections depends strongly on the design and functional diversity of the library of binding molecules employed, and on the performance of the selection strategy.
Until a relationship of binding trust is established and cultural barriers between case officers and analysts are forever erased, success will be predictably slow and incremental.
Such prediction of binding sites which depends on structural similarity of protein surfaces is useful and accurate and can enjoy success in structures with dissimilar folding patterns.
The pro-independence SNP is in power in Scotland's devolved government and has achieved the landmark success of negotiating with the UK government this binding referendum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com