Preadipocytes resident in different fat depots are distinct cell subtypes that differ in developmental gene expression and capacities for replication, differentiation, and apoptosis (Yamamoto et al. 2010; Kirkland et al., 1990; Tchkonia et al., 2001, 2002, 2006b, 2007b).
IV A is further divided into subtypes that differ in the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA).
In the last decade, comprehensive whole genome expression profiling by microarray technology has extensively defined breast cancer into distinct molecular subtypes that differ in terms of patient outcome and response to systemic treatment.
Pediatric ALL is a heterogeneous disease consisting of various leukemia subtypes that differ markedly in their response to chemotherapy.
It is presented as a collection of distinct disease subtypes that differ in disease progression, treatment response, and disease-free survival [ 1– 5].
Rhabdomyosarcoma is characterised by having two major subtypes that differ in histology, degree of differentiation, and prognosis: the embryonal form (ERMS) constituting approximately two-thirds of all RMS and the rarer alveolar form (ARMS) (Newton et al, 1995).
